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In vitro & in vivo Toxicology

GBA Group - In vitro and in vivo toxicology

Performed in-house in a quality controlled way

The GBA Group's service portfolio on in vitro and in vivo toxicology service offers you a complete workflow. De-risk either your early stage drug discovery or late stage development programs with us. In vitro toxicology assays are performed in-house in a quality controlled way.

We offer in vivo non-GLP toxicology studies in-house with rodents, e.g. for the early evaluation of the toxicological potential of drug candidates during development. Thereby, we support all studies with the required bioanalytical analysis. Furthermore, GLP bioanalysis of samples from all animal species can be performed.

Contact at Pharmacelsus

Your contact at Pharmacelsus

MUDr. Maria Li
Director Business Development

Mobile: +49 173 889 4288

Mail: m.li@gba-pharma.com

In vitro Toxicology

Cytotoxicity

  • Test systems
    • Established cell lines and primary cells, 2D–monolayer, suspension and 3D-organoid cultures
  • Analysis
    • Fluorescence, luminescence, absorbance
  • Indicator
    • Resazurin, XTT, MTT, ATP, LDH
  • Readout
    • Viability, Cell Membrane Damage, energy content

Mitochondrial Toxicity

  • Test Systems
    • HepG2, HepG2-Oxphos
  • Analysis
    • Fluorescence, luminescence
  • Indicator
    • Resazurin, XTT, ATP
  • Readout
    • Viability
  • Format
    • 96-Well Plate/Plate Reader
    • Multiplexing of analytical endpoints available

Metabolite Toxicity

  • Test systems
    • HepG2 w/ and w/o metabolic activation - by S9-Fraction
  • Analysis
    • Luminescence
  • Indicator
    • ATP
  • Format
    • 96-Well Plate/Plate Reader
  • Metabolite identification via LC-MS
  • Reactive metabolite trapping in liver microsomes

Immunotoxicity

  • Test Systems
    • PMBC, monocytes, blood
  • Analysis
    • Luminex technology
  • Readout
    • Lymphocyte subsets, cytokine levels
  • Format
    • 96-Well Plate/Plate Reader, Luminex
  • Can be combined with other systems e.g. viability assays
  • Recommended assays according to ICH S8

Hepatotoxicity

  • Test systems
    • HepG2, primary hepatocytes
  • Analysis
    • Fluorescence, luminescence, Luminex technology
  • Indicator
    • Resazurin, ATP
  • Readout
    • Viability, energy content, biomarker levels
  • Format
    • 96-Well Plate/Plate Reader, Luminex

Allergic Response / Histamine Release

  • Test systems
    • Peritoneal mastocytes
  • Analysis
    • Absorption
  • Indicator
    • O-phtaldialdehyde
  • Readout
    • Histamine release
  • Format
    • 96-Well Plate/Plate Reader

In vivo Toxicology

Species

  • Rodents

Routes of Administration

  • Oral
  • Intraperitoneal
  • Intravenous
  • Subcutanous
  • Dermal
  • Rectal
  • Others
    • (please contact us)

Acute Toxicity

  • Systemic toxicity
  • Phototoxicity
  • Local tolerance
  • Skin sensitisation and irritation
  • Others
    • (please contact us)

Subchronic & Chronic Toxicity

  • Rodents
  • DRF studies
  • MTD studies
  • Toxicokinetics

Reproductive Toxicity

  • Fertility and reproduction

Pathology

  • Histology
  • Immuno-histopathology
  • Others
    • (please contact us)

Further toxicological assays are available on request.

The experienced and highly committed GBA Group team offers a variety of different services the following in Areas:

GBA Group - In vitro ADME

In vitro ADME

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GBA Group - In vivo DMPK

In vivo DMPK

GBA Group - In vitro & in vivo Toxicology

In vitro & in vivo Toxicology

GBA Group - G(C)LP & non-GLP Bioanalytics

G(C)LP & non-GLP Bioanalytics

GBA Group - Biomarker Services

Biomarker Services

GBA Group - In vitro & in vivo Pharmacology

In vitro & in vivo Pharmacology

GBA Group - Preclinical Services

Preclinical Services

GBA Group Pharma

GBA Group Pharma

Business Development

Contact us!

To learn more about us and what we can do for you please contact our Director Business Development.

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