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In Vitro & In Vivo Toxicology

Performed in-house in a quality controlled way

The Pharmacelsus service portfolio on In Vitro and In Vivo Toxicology service offers you a complete workflow. De-risk either your early stage drug discovery or late stage development programs with us. In Vitro Toxicology assays are performed in-house in a quality controlled way. In Vivo Toxicology studies according to national and international guidelines are available on rodent and non-rodent species in cooperation with our trusted partner. In Vivo non-GLP rodent studies are performed in house.

In Vitro Toxicology

Cytotoxicity

  • Test Systems Established Cell Lines and Primary Cells, 2D–Monolayer, Suspension and 3D-Organoid Cultures
  • Analysis

Fluorescence, Luminescence, Absorbance

  • Indicator

Resazurin, XTT, MTT, ATP, LDH

  • Readout

Viability, Cell Membrane Damage, Energy Content

Mitochondrial Toxicity

  • Test Systems

HepG2, HepG2-Oxphos

  • Analysis

Fluorescence, Luminescence

  • Indicator

Resazurin, XTT, ATP

  • Readout

Viability

  • Format

96-Well Plate/Plate Reader

  • Multiplexing of Analytical Endpoints Available

Metabolite Toxicity

  • Test Systems

HepG2 w/ and w/o Metabolic Activation - by S9-Fraction

  • Analysis

Luminescence

  • Indicator

ATP

  • Format

96-Well Plate/Plate Reader

  • Metabolite Identification via LC-MS
  • Reactive Metabolite Trapping in Liver Microsomes

Immunotoxicity

  • Test Systems

PMBC, Monocytes, Blood

  • Analysis

Luminex Technology

  • Readout

Lymphocyte Subsets, Cytokine Levels

  • Format

96-Well Plate/Plate Reader, Luminex

  • Can be Combined with Other Systems e.g. Viability Assays
  • Recommended assays according to ICH S8

Hepatotoxicity

  • Test Systems

HepG2, Primary Hepatocytes

  • Analysis

Fluorescence, Luminescence, Luminex - Technology

  • Indicator

Resazurin, ATP

  • Readout

Viability, Energy Content, Biomarker Levels

  • Format

96-Well Plate/Plate Reader, Luminex

Allergic Response / Histamine Release

  • Test Systems

Peritoneal Mastocytes

  • Analysis

Absorption

  • Indicator

O-Phtaldialdehyde

  • Readout

Histamine Release

  • Format

96-Well Plate/Plate Reader

In Vivo Toxicology*

Species

  • Rodents
  • Non-Rodent Species (please contact us)

Routes of Administration

  • Oral
  • Intraperitoneal
  • Intravenous
  • Subcutanous
  • Dermal
  • Rectal
  • Others (please contact us)

Acute Toxicity

  • Systemic Toxicity
  • Phototoxicity
  • Local Tolerance
  • Skin Sensitisation and Irritation
  • Others (please contact us)

Subchronic & Chronic Toxicity

  • Rodents and Non-Rodents
  • DRF Studies
  • MTD Studies
  • Toxicokinetics

Reproductive Toxicity

  • Fertility and Reproduction

Pathology

  • Histology
  • Immuno-Histopathology
  • Others (please contact us)

Further toxicological assays are available on request.

Please contact us for your specific toxicology study.

For In Vitro Toxicology

Dr. Julia Susewind

In Vitro Toxicology
susewind@pharmacelsus.de

For In Vivo Toxicology

Anika Christoffel

In Vivo Pharmacology & Pharmacokinetics
christoffel@pharmacelsus.de

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