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PharmaPharmacelsus - Preclinical ServicesIn vitro ADME

In vitro ADME

Professionalism and Flexibility

The in vitro ADME team of Pharmacelsus combines professionalism of the pharmaceutical industry with the flexibility to adapt standard assays for your specific challenges. We use a consultative approach to set-up tailor-made assays together with you. Studies are conducted to meet regulatory requirements.

Evaluate the “druggability” of your compounds by the following set of in vitro ADME assays.

Physico-Chemical Parameters

  • Chemical stability
  • Aqueous solubility

Stability in Biological Matrices

  • Blood
  • Plasma
  • Intestinal fluids
  • Further matrices on request
  • All preclinical species available

Membrane Permeability

  • PAMPA
  • Artificial BBB
  • Bidirectional Caco2
  • PgP interaction
  • Nuclear uptake

Interaction with Drug Transporters*

  • ABC-ATP binding
  • SLC transporters:
    inhibition/uptake
  • PgP interaction

*in cooperation

Protein Binding Mechanism

  • PPB (crossfiltration or Rapid Equilibrium Dialysis)
  • SPB (crossfiltration or Rapid Equilibrium Dialysis)
  • Blood partitioning
  • Microsomal binding

Brain Tissue Binding

  • Rat, mice tissue
  • Ultrafiltration
  • Rapid Equilibrium Dialysis

Metabolic Stability

  • Liver or intestinal microsomes
  • Liver or intestinal S9 fraction
  • Hepatocytes
  • All preclinical species available

Reactive Metabolite Trapping

  • Liver microsomes
  • GSH

Metabolite Identification

  • Liver or intestinal microsomes
  • Liver or intestinal S9 fraction
  • Hepatocytes
  • Metabolic pathway

CYP Inhibition

  • Recombinant human CYPs
  • IC₅₀ determination
  • Human liver microsomes*
  • Mode of inhibition, inhibition kinetics

*according to EMA/FDA Guidelines

CYP Induction

  • Hepa RG®
  • Human hepatocytes
  • Functional activity
  • mRNA

CYP Phenotyping

  • Recombinant human CYPs
  • Loss of parent compound
  • Clint
  • Half-Life
  • Formation of major Phase 1 metabolites and metabolic Pathway Elucidation
ADME Studies

ADME Studies

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Your contact at Pharmacelsus

MUDr. Maria Li
Director Business Development
Mobile: +49 173 889 4288
​Li@pharmacelsus.de

Business Development

Contact us!

To learn more about us and what we can do for you please contact our Director Business Development

The experienced and highly committed Pharmacelsus team offers a variety of different services the following in Areas.

In vivo DMPK

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In vitro & in vivo Toxicology

G(C)LP & non-GLP Bioanalytics

Biomarker Services

In vitro & in vivo Pharmacology

Services for Biologics

Preclinical Services

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