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PharmaPreclinical Services – PharmacelsusIn vivo DMPK

In vivo DMPK

Flexibility & Speed

Flexibility in study design and meeting demanding time lines is the strength of the Pharmacelsus in vivo team. We offer DMPK studies in mice, rats, guinea pigs and hamsters. The Pharmacelsus offering includes complete workflow studies (in-life part, bioanalysis and PK evaluation, biomarker assessment ). Non-GLP bioanalysis and GLP bioanalysis of samples from all animal species can be performed.


  • Rodents

Application Routes

  • Intravenous (bolus or infusion)
  • Oral (liquid, capsules)
  • Intraperitoneal
  • Subcutaneous (incl. osmotic - minipumps)
  • Intramuscular
  • Intradermal
  • Intranasal
  • Topical
  • Intravitreal
  • Intraportal
  • Single, repeated and cassette dosing

Exploratory PK Studies

  • Microsampling/snapshot PK
  • Cassette dosing
  • Major metabolites

Surgical Methods

  • Cannulation (Rat)
    • vena jugularis (neck or head attachment)
    • portal vein* (e.g. for evaluation of first-pass effect)
    • bile duct* (e.g. for evaluation of entero-hepatic circulation)
  • Bile duct ligation (Rat)
  • Castration

*animal surgery is conducted at the provider of rats and mice.

Sampling Methods

  • Jugular catheter
  • Tail vein or artery
  • Sublingual vein
  • Facial vein
  • Plexus retrobulbaris
  • Heart puncture (terminal)
  • Microsampling
  • Tissue perfusion
  • Metabolic cage

Sample Types

  • Whole blood, plasma, dried blood spots
  • Excreta
    • urine
    • faeces
    • bile
  • Bronchioalveolare lavage fluid
  • Cerebrospinal fluid
  • Tissues/organs


  • All Markers that can be quantified in biological matrices by validated immuno-assay or LC-MS-methods
  • Sample processing for histology
  • Haematology

Full PK Studies

  • Dose proportionality
  • Organ distribution, excretion, mass - balance
  • Metabolite identification
  • First pass effect

Ex vivo Investigation

  • Brain slice method

All experimental procedures are approved by and conducted in accordance with the regulations of the local Animal Welfare authorities. The Pharmacelsus in vivo department is frequently audited by clients with positive results.

In vivo Services

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Your contact at Pharmacelsus

MUDr. Maria Li
Director Business Development

Mobile: +49 173 889 4288

Business Development

Contact us!

To learn more about us and what we can do for you please contact our Director Business Development.

The experienced and highly committed Pharmacelsus team offers a variety of different services the following in Areas.

In vitro ADME


In vitro & in vivo Toxicology

G(C)LP & non-GLP Bioanalytics

Biomarker Services

In vitro & in vivo Pharmacology

Preclinical Services

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