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In vitro ADME

GBA Group - In vitro ADME

Professionalism and Flexibility

The in vitro ADME team of the GBA Group combines professionalism of the pharmaceutical industry with the flexibility to adapt standard assays for your specific challenges. We use a consultative approach to set-up tailor-made assays together with you. Studies are conducted to meet regulatory requirements.

Evaluate the “druggability” of your compounds by the following set of in vitro ADME assays.

Contact at Pharmacelsus

Your direct contact

MUDr. Maria Li
Director Business Development

Mobile: +49 173 889 4288


Physico-Chemical Parameters

  • Chemical stability
  • Aqueous solubility

Stability in Biological Matrices

  • Blood
  • Plasma
  • Intestinal fluids
  • Further matrices on request
  • All preclinical species available

Membrane Permeability

  • Artificial BBB
  • Bidirectional Caco2
  • PgP interaction
  • Nuclear uptake

Interaction with Drug Transporters*

  • ABC-ATP binding
  • SLC transporters:
  • PgP interaction

*in cooperation

Protein Binding Mechanism

  • PPB (crossfiltration or Rapid Equilibrium Dialysis)
  • SPB (crossfiltration or Rapid Equilibrium Dialysis)
  • Blood partitioning
  • Microsomal binding

Brain Tissue Binding

  • Rat, mice tissue
  • Ultrafiltration
  • Rapid Equilibrium Dialysis

Metabolic Stability

  • Liver or intestinal microsomes
  • Liver or intestinal S9 fraction
  • Hepatocytes
  • All preclinical species available

Reactive Metabolite Trapping

  • Liver microsomes
  • GSH

Metabolite Identification

  • Liver or intestinal microsomes
  • Liver or intestinal S9 fraction
  • Hepatocytes
  • Metabolic pathway

CYP Inhibition

  • Recombinant human CYPs
  • IC₅₀ determination
  • Human liver microsomes*
  • Mode of inhibition, inhibition kinetics

*according to EMA/FDA Guidelines

CYP Induction

  • Hepa RG®
  • Human hepatocytes
  • Functional activity
  • mRNA

CYP Phenotyping

  • Recombinant human CYPs
  • Loss of parent compound
  • Clint
  • Half-Life
  • Formation of major Phase 1 metabolites and metabolic Pathway Elucidation

Our Flyers

ADME Studies

ADME Studies

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The experienced and highly committed GBA Group team offers a variety of different services the following in Areas:

GBA Group - In vitro ADME

In vitro ADME

GBA Group - In vivo DMPK

In vivo DMPK

GBA Group - In vitro & in vivo Toxicology

In vitro & in vivo Toxicology

GBA Group - G(C)LP & non-GLP Bioanalytics

G(C)LP & non-GLP Bioanalytics

GBA Group - Biomarker Services

Biomarker Services

GBA Group - In vitro & in vivo Pharmacology

In vitro & in vivo Pharmacology

GBA Group - Preclinical Services

Preclinical Services

GBA Group Pharma

GBA Group Pharma

Business Development

Contact us!

To learn more about us and what we can do for you please contact our Director Business Development.

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