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Container Closure Integrity Tests

The integrity of a container

The integrity of a container is especially important for reasons that are quite understandable. In general, this is checked using microbiological tests (microbial ingress into the packaging) or color tests (dye ingress into the packaging). 

GBA Pharma Labs have established methods for chemical testing using a methylene blue solution (called the "blue bath test") for a variety of sealing material combinations. In addition to the sample containers, these methods utilize both positive and negative controls. 

The container seal combinations include:

  • Glass Vials with Rubber or Silicon Seals (Various Sizes)
  • Syringes with Rubber
  • Carpules with Rubber
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