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Methods of Analysis

We will support you with our full analytical service

No matter if you have to meet specific analytical requirements or if your new project comes with tight timelines, we will support you with our full analytical service. If time and capacity is low, we will help you to meet the timeline with our know-how, our equipment and our manpower. 

We are offering the following analytical methods: 

  • HPLC and UPLC: Detection by UV, VIS, DAD, Fluorescence, RI, ECD, ELSD, PAD, Conductivity, CAD

  • UPLC

  • Gas Chromatography: Detection by means of: FID, PND, TCD Choice with Headspace-GC

  • Coupled Techniques: HPLC-MS, GC-MS, HS-GC-MS, LC-MS-IT-TOF

  • Ion Chromatography: Anions and Cations 

  • Capillary Electrophoresis for Pharmaceutical Issues: Capillary Zone Electrophoresis CZE, Micellar Electrokinetic Chromatography (MEKC), SDS-PAGE)

  • Biochromatography / GPC 

  • LC with Pulsed Amperometric Detection and Post-Column Derivatisation 

  • TLC: Quantitative and Qualitative 

  • IR: FT-IR 

  • Low-Pressure Chromatography

  • Gel-Electrophoresis

  • Enzyme Immunoassay

  • AAS: Graphite Furnace and Flame, Hydride 

  • ICP-OES, ICP-MS

  • Amino Acid Analyzer



Other Technologies


Comparative Dissolution USP I & II (basket and paddle), USP IV (flow through cells), spectrophotometry, Karl Fischer titration, coulometric titration, potentiometric titration, halogen drying, decay time determination, friability, hardness testing, optical rotation, osmolality, eg. 

Our Core Competences and Special Expertise

Our Core Competences and Special Expertise in Chemical-Physical and Pharmaceutical Analysis: 

  • Amino Acid Analysis (e.g. determination of ninhydrin-positive substances)

  • Analysis of Antibiotics

  • Analysis of Substances without Chromophore (e.g. using LC-ELSD, LC-CAD, LC-RI)

  • Assistance with Downstream Processing by Analyzing for Small Molecules (e.g. Methotrexate, Aminoglycoside Antibiotics, Polysorbates, Simethicone, Poloxamers, Triton X-100) in Pharmaceuticals Produced with Biotechnology

  • Trace Analysis of Beta-Propionic Acid Lactone in Vaccines

  • Elemental Analysis (AAS, ICP-OES, ICP-MS)

  • Extractables and Leachables Studies

  • ICH Q3D Elemental Impurities Testing

  • Genotoxic Impurities

  • Determination of Residual Solvents

  • Release Testing (USP I, II, IV)

  • Identification of Impurities (LC-MS, GC-MS)

  • Capillary Electrophoresis (e.g. Capillary Zone Electrophoresis, CZE, Micellar Electrokinetic Capillary Chromatography, MEKC)

  • MS Coupling (e.g. GC-MS, LC-MS, including LC-MS-Q-TOF)

  • Protein Analysis (e.g. Erythropoietin, EPO, Insulin, Antibodies, Peptide Mapping, Determination of C-Termina and N-Termina, Aggregate Determination, Glycan Analysis)

  • Quality Control of Primary Packaging Materials (Glass, Plastic), including Package Leak Testing

  • Analysis of Highly Potent Substances (e.g. Cytostatic Agents) and Photo-Labile Compounds


Device List

Device List and Analysis Methods

If the analysis that you need cannot be found on the list of analytical techniques, then the device list should give an indication of the methods we have established in our labs. For the equipment listed below, we generally have multiple devices available at several locations which ensures that your order will be processed on time. If the device that you are looking for is not on this list, then please contact our marketing department and we will gladly provide you with assistance. 

Amino Acid Analyzer:

  • Amino Acid Analyzer for Ninhydrin-Positive Substances


Bio-Inert LC Systems:

  • Bio LC-ECD

  • Bio LC Conductivity Sensor

Biological Methods:

  • ELISA

  • Gel Electrophoresis

  • Western Blot

Chemical-Physical and Pharmaceutical Tests:

  • Abrasion Resistance

  • Refractive Index

  • Hardness

  • Density

  • Moisture Determination Using a Glove Box

  • Freezing Point

  • Freeze-Drying (Speed Vac)

  • Gravimetry (Loss on Drying, Total Ash, Residue on Ignition, Sulfated Ash)

  • Gradation Testing (Sieve Analysis)

  • Halogen Drying

  • Conductivity

  • Microscopy (Light)

  • Wet Chemistry (Ph. Eur, BP, USP, JP)

  • Osmotic Concentration

  • Particle Counting (Sub-Viisible Particles, HIAC)

  • Particle Determination (Visible Particles, according to Ph.Eur. 2.9.20)

  • Polarimetry

  • Oxygen Determination

  • Melting Point

  • Bulk Density and Tapped Density (incl. Hausner Ratio)

  • Flash Point

  • Nitrogen Determination according to Kjeldahl

  • Tablet Hardness Testing

  • Titration, Automatic Titrators (e.g. Potentiometric)

  • Turbidity Measurements

  • Viscosity Testing (Torque Measurement, Cone/Plate)

  • Determination of Moisture Content according to Karl-Fischer – Coulometric Ph.Eur.2.5.32

  • Determination of Moisture Content according to Karl-Fischer – Titration Ph.Eur.2.5.12

  • Determination of Moisture Content according to Karl-Fischer – Stromboli Oven

  • Disintegration Testing (Suppositories, Pills)


Elemental Analyses:

  • AAS (Flame, Graphite Furnace, Hybrid – Batch and FIA Techniques)

  • ICP-MS

  • ICP-OES

Active Ingredient Dissolution:

  • Dissolution Testing using flow-through cells according to USP IV for Active Ingredients with Low Solubility, Granules, Suppositories, Soft Gelatin Capsules

  • Dissolution Testing according to USP-I & USP-II; Offline and Online UV Detection

GC Systems:

  • Headspace-GC-FID

  • GC-ECD

  • GC-FID

  • GC-MS

  • GC-PND

  • GC-WLD

  • GC-PTV Injection System

  • GC-Split/Splitless


HPTLC/TLC:

  • HPTLC/TLC Qualitative Analysis with Photo Documentation (UV, VIS, Fluorescence)

  • HPTLC Quantitative

LC Systems:

  • HPLC-CAD

  • HPLC-DAD

  • HPLC-ECD

  • HPLC-ELSD

  • HPLC-Fluorescence

  • HPLC-Conductivity Detector

  • HPLC-MS

  • HPLC-MS-QTOF

  • HPLC-PAD

  • HPLC-RI

  • HPLC-UV/VIS

  • HPLC-Post-Column Derivatization

  • GPC

  • GPC-RI (Molar Mass Distribution)

  • Ion Chromatography (Anions, Cations, Ion Suppression)

  • UPLC-DAD

  • UPLC-MS

  • UPLC-UV


Mass Spectrometry:

  • GC-MS

  • HPLC-MS

  • HPLC-MS-QTOF

  • UPLC-MS


Spectrophotometry:

  • FT-IR (ATR)

  • UV/VIS Spectrophotometer

Stability Studies:

  • Temperature-Controlled Stability Rooms and Chambers (all ICH Conditions; Special Conditions from -80°C to +55°C)

  • Photostability Tests: Atlas Suntester, WUT Stability Chamber (ICH Q1B)
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